Complete Mississippi River Cruise
Relax and enjoy the passing landscapes as we make our way along the Mississippi River from New...
Our Cruise Destinations
American Cruise Lines offers a variety of captivating cruise itineraries throughout the United States, including the Mississippi River region, Southeast, Northeast, Pacific Northwest, and Alaska.
Mississippi River Cruises
Cumberland River Cruise
Cruise from Nashville to St. Louis, following the Cumberland and Mississippi Rivers on a route of...
Grand Heartland Cruise
Enjoy an epic 15-day journey on our Grand Heartland Cruise. This cruise on the Mississippi River...
Highlights of the Mississippi River
Your round-trip Mississippi River adventure begins and ends in New Orleans, a melting pot of...
Lower Mississippi River Cruise
Traveling the Lower Mississippi with American Cruise Lines is an experience like no other. Our...
Mississippi River Gateway Cruise
Cruise the Mississippi River from the banks of the Bayou to the shores of St. Louis. Your journey...
New Orleans - New Orleans
Board one of our brand new riverboats, as we celebrate the music, history, and culture of the Lower ...
Ohio River Cruise
Experience the picturesque waterways of the Mississippi and Ohio Rivers on this 11-day adventure....
Upper Mississippi River Cruise
The dramatic landscapes of the Upper Mississippi River have long inspired artists, writers, and...
New England Cruises
Grand New England Cruise
Discover the majestic seafaring heritage of coastal towns and quaint island villages on the 11-day...
Hudson River Cruises
Surrounded by the Catskill Mountains on the western shore and the Taconic and Berkshire Hills to...
Maine Coast and Harbors Cruise
People have been drawn to the spectacular coast of Maine throughout history. As your small ship...
New England Islands Cruise
Travel with American Cruise Lines as we discover the New England Islands. Each day is filled with...
Pacific Northwest & Alaska Cruises
Alaska Inside Passage Cruise
Discover the majestic splendor of a summer in Alaska on an incredible 15-day journey. Cruise the...
Alaskan Explorer Cruise
Experience a once-in-a-lifetime adventure, on our brand new 11-day Alaskan Explorer Cruise. Venture ...
Columbia and Snake Rivers Cruise
Embrace your inner pioneer as you travel along the epic route forged by Lewis and Clark more than...
Grand Puget Sound
Your magnificent voyage begins in the seaport city of Seattle, harbor hopping through the Puget...
Highlights of the Columbia River Cruise
Our Highlights of the Columbia River cruise offers the best of the Pacific Northwest with the...
Northwest Pioneers Cruise
Experience the historic journey of the intrepid explorers Lewis and Clark, while admiring the...
Puget Sound and San Juan Islands Cruise
Travel to where the Cascade and Olympic Mountains meet the sea, forming the stunning Puget Sound...
Southeast Alaska Cruise
Experience the breathtaking scenery of Alaska in the sophisticated atmosphere of the region’s most...
Southeast Cruises
American Revolution Cruise
Travel back to the dawn of America, on our brand new 11-day American Revolution cruise. Explore the ...
Chesapeake Bay Cruise
The Chesapeake Bay abounds in history and culture. From the vibrant harbor of Baltimore, travel to...
East Coast Inland Passage Cruise
Cruise the East Coast Inland Passage through a rich past that has influenced our country since the...
Great Rivers of Florida Cruise
On this epic cruise, sail a route that adventurous passengers first followed in the 19th century in ...
Historic South and Golden Isles Cruise
The Intracoastal Waterway, home to some of the most beautiful historic cities in America, is a...
Mid-Atlantic Inland Passage Cruise
On this 8-day voyage, enjoy the tranquil beauty and pristine wilderness found along the...
Themed Cruises
Christmas Cruise
Join us for a joyful celebration aboard our Christmas Cruise. Explore the Mississippi River on our...
Learn More
Nashville Country & Blues Cruise
Blues and Country music are distinctly American, with deep roots on the banks of the Mississippi...
Learn More
Lobsterbake Cruise
Mention New England and one of the first things that comes to mind is lobster. Enjoy a traditional...
Learn More
Civil War Cruise
Delve deep into the history of the Civil War on this special theme cruise which explores...
Learn More
Music Cruise
Delight in the sounds of Jazz and Blues that fill the air as we cruise the Mississippi River and...
Learn More
Lewis & Clark Cruise
Two hundred years ago, Lewis and Clark set out on their pioneering journey into the West. Follow...
Learn More
Tulip Festival Cruise
Springtime in the Pacific Northwest is a wonderful time with one of the most magnificent...
Learn More
Thanksgiving Cruise
Celebrate Thanksgiving with American Cruise Lines, as we cruise the Historic South from...
Learn More
Mark Twain Cruise
Few American authors are as beloved as Samuel Clemens, better known by his pen name, Mark Twain. On ...
Learn More
Food & Wine Cruise
The Pacific Northwest is known for its delicious seafood and delectable wines. Savor exquisite,...
Learn More
New Years Cruise
Let American Cruise Lines help you ring in the New Year as we travel round-trip from New Orleans....
Learn More
Culinary Cruise
The Culinary Cruise along the Lower Mississippi River cruise is perfect for food lovers who relish...
Learn More
Puget Sound Fall Foliage
Experience brilliant fall foliage with American Cruise Lines' Fall Cruises as we cruise the Puget...
Learn More
Fall Foliage
Experience brilliant fall foliage with American Cruise Lines' on our fall cruises along the Hudson...
Learn More
Crabfest Cruise
Cruise the scenic Chesapeake Bay and delight your palate with fresh seafood from the "Blue Crab...
Learn MoreGet ready for an Ultimate Travel Experience
Request a free 2019-2020
US Cruise Guide NOW!
The American Cruise Lines Difference
Delicious Cuisine
Gracious Service
Nightly Entertainment
First-Class Staterooms